Clinical Funded Projects

A portion of our budget goes to competitive research proposals that support our scientific mission. We consider research proposals that:

  1. Address military-relevant traumatic brain injury (TBI) and/ or its comorbidities 
  2. Exhibit high scientific merit based on potential innovation and impact on the field
  3. Advance and accelerate TBI research that improves recovery of the Warfighter through:
    • fostering collaborative efforts across CNRM investigators
    • leveraging CNRM resources
    • facilitating synergistic efforts with other Military Health System activities

Below are summaries of our active clinical funded projects.

Active Clinical Funded Projects

Development of Bench and Preclinical MRI Methods to Assess Glymphatic Clearance in the Living Brain

Principal Investigator: Peter Basser, Ph.D.
Aim: To develop a family of new non-invasive in vivo dispersion MRI methods to characterize cerebrospinal fluid transport within each brain voxel. These approaches will be used to characterize the efficacy of brain fluid mixing.

Imaging [18F] AV1451 and [18F] AV45 in Military Service Members with Blast-related Mild Traumatic Brain Injury

Principal Investigators: Dara Dickstein, PhD; Grant Bonavia, MD, PhD
Aim: To assess the brain pathology associated with blast exposure by:
  1. Performing two different positron-emission tomography (PET) scans to identify tau deposits and amyloid-beta deposits in Service Members with a history of blast exposure and mild TBI
  2. Conducting additional imaging techniques and behavioral tests to assess behavioral and memory functions
ClinicalTrials.Gov Link: N/A
Study Flyer: N/A

Improving Sleep Using Bright Light Therapy

Principal Investigators: Jessica Gill PhD, RN, FAAN; Miranda Lim, MD, PhD
Aims: Tests the effect several at-home, easy to use devices have on sleep and cognition in veterans with or without a history of TBI. 
Research Locations: Oregon Health and Sciences University and the VA Portland Health Care System; however, this study is also able to be conducted remotely

Investigating the Biological Mechanisms of Alpha-delta Sleep

Principal Investigators: David Brody, MD, PhD; Jackie Gottshall, PhD; John "Kent" Werner, MD, PhD (mentor)
Aims: Alpha-delta sleep is a poorly understood electroencephalogram sleep pathology that has been associated with non-restorative sleep. This study aims to 1). Characterize the prevalence and epidemiology of alpha-delta sleep following a traumatic brain injury and 2). Evaluate the relationship alpha-delta sleep has with slow wave sleep and wakeful cognitive performance.

Noninvasive Detection and Localization of Cortical Spreading Depolarizations

Principal Investigators: David Brody, MD, PhD; Mihika Gangolli, PhD; Dzung Pham, PhD (mentor)

Aim: Develop and test a diffusion MRI methodology that can noninvasively monitor cortical spreading depolarizations (e.g. changes that take place in the brain during migraine auras).

Reconsolidation of Traumatic Memories to Resolve Post-traumatic Stress Disorder

Principal Investigator: Michael Roy, MD, MPH, COL (Ret)
Aim: To evaluate the effectiveness of Reconsolidation of Traumatic Memories in reducing post-traumatic stress disorder symptom severity in active duty or retired service members.
Location: Walter Reed National Military Medical Center; however, this study is also able to be conducted remotely