Neuropathological and Neuroradiological Research

The Neuropathology-Neuroradiology Integration Core

The Neuropathology-Neuroradiology Integration Core is a novel union of two complementary but distinct fields: neuropathology and neuroradiology.

The Core includes Dr. Daniel Perl's Neuropathology Research Division and Dr. Peter Basser’s Section on Quantitative Imaging and Tissue Sciences. They are working to develop and test new magnetic resonance imaging (MRI) approaches that can potentially detect mild traumatic brain injury (TBI)-related structural abnormalities in living patients.

Unfortunately, standard neuroimaging approaches (e.g., CT scan and conventional MRI) are not sensitive enough to detect microscopic injuries and/or tissue damage following mild TBI. Instead, these abnormalities can only be identified post-mortem using laborious neuropathological methods. Having accessible clinical MRI methods that could detect changes in the brain after a mild TBI would be a tremendous advancement for the medical community. This is because mild TBI accounts for almost 80% of all TBIs experienced by civilians and military personnel.

The Core is working hard to discover, if possible, one or more quantitative MRI biomarkers that can effectively detect and confirm sequelae of mild TBI found by neuropathological methods. If the team achieves this milestone, a subsequent goal is to use these objective MR imaging methods to advance TBI diagnosis, clinical trial inclusion, and treatment guidance in service members.

Core-related Publications

Benjamini, D., Iacono, D., Komlosh, M. E., Perl, D. P., Brody, D. L., & Basser, P. J. (2021). Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brainBrain: a journal of neurology, awaa447. Advance online publication. https://doi.org/10.1093/brain/awaa447

Benjamini, D., & Basser, P. J. (2020). Multidimensional correlation MRINMR in biomedicine33(12), e4226. https://doi.org/10.1002/nbm.4226