Neuroradiological and Neuropathological Research

The Neuroradiology-Neuropathology Integration Core

The Neuroradiology-Neuropathology Integration Core is a novel union of two complementary but distinct fields: neuroradiology and neuropathology.

The Core includes Dr. Peter Basser’s Section on Quantitative Imaging and Tissue Sciences, NICHD, and Dr. Dan Benjamini’s Multiscale Imaging and Integrative Biophysics Unit, NIA in association with Dr. Daniel Perl's Neuropathology Research DivisionUSUHS. Dr. Basser is the Director of this Core and Dr. Benjamini is its Associate Director. Together, they are working to develop and test new magnetic resonance imaging (MRI) approaches to potentially detect traumatic brain injury (TBI) in live subjects and patients using curated neuropathological brain tissue provided by Dr. Perl’s group.

Unfortunately, standard neuroimaging approaches (e.g., CT scan and conventional MRI) are not sensitive or specific enough to detect microscopic injuries and/or tissue damage following TBI. Instead, these abnormalities can only be identified post-mortem using laborious neuropathological methods. Having accessible clinical MRI methods that could detect changes in the brain after a TBI would represent a tremendous advance. A special focus of this Core has been to characterize and detect Blast TBI, which is increasingly afflicting our warfighters.  Recently, we have developed MRI strategies to detect blast injury in Dr. Perl’s neuropathological tissue specimen; our hope is to migrate these new imaging methods to the clinic.

The Core is working hard to discover, if possible, one or more quantitative MRI biomarkers that can effectively detect and confirm sequelae of TBI found by neuropathological methods. If the team achieves this milestone, a subsequent goal is to use these objective MR imaging methods to advance TBI diagnosis, clinical trial inclusion, and treatment guidance in service members.

CORE-RELATED PUBLICATIONS

Benjamini, D., Bouhrara, M., Iacono, D., Komlosh, M. E., Perl, D. P., Brody, D. L., & Basser, P. J. (2021). Multidimensional MRI for Characterization of Subtle Axonal Injury Accelerated Using an Adaptive Nonlocal Multispectral Filter. Frontiers in Physics, e-pub ahead of print.

Avram, A.V., Sarlls, J.E., & Basser, P. J. (2021). Whole-Brain Imaging of Subvoxel T1-Diffusion Correlation Spectra in Human Subjects. Frontiers in Neuroscience, 15, 671465.

Benjamini, D., Iacono, D., Komlosh, M. E., Perl, D. P., Brody, D. L., & Basser, P. J. (2021). Diffuse axonal injury has a characteristic multidimensional MRI signature in the human brainBrain, 144 (3), 800-816. https://doi.org/10.1093/brain/awaa447

Pas, K., Komlosh, M. E., Perl, D. P., Basser, P. J., & Benjamini, D. (2020). Retaining information from multidimensional correlation MRI using a spectral regions of interest generatorScientific Reports, 10, 3246. 

Benjamini, D., & Basser, P. J. (2020). Multidimensional correlation MRINMR in Biomedicine33(12), e4226. https://doi.org/10.1002/nbm.4226