Preclinical Funded Projects
A portion of our budget goes to competitive research proposals that support our scientific mission. We consider research proposals that:
- Address military-relevant traumatic brain injury (TBI) and/ or its comorbidities
- Exhibit high scientific merit based on potential innovation and impact on the field
- Advance and accelerate TBI research that improves recovery of the Warfighter through:
- fostering collaborative efforts across CNRM investigators
- leveraging CNRM resources
- facilitating synergistic efforts with other Military Health System activities
Below are summaries of our active preclinical CNRM funded projects.
Active Preclinical Funded Projects
Blast Traumatic Brain Injury’s Effect on the Limbic-HPA Axis
- Study the fear-related behavioral outputs associated with limbic regions that regulate the HPA axis
- Examine the long-term effect mild TBI has on the HPA axis
- Examine the long-term effect mild TBI has on prefrontal cortex neurons and the paraventricular nucleus
Inhibition of AEA Hydrolysis and Oxidation in Traumatic Brain Injury
Meningeal and Neurovascular Responses to Blast-induced Traumatic Brain Injury
Novel N-docosahexaenoylethanolamine Analogues to Improve Traumatic Brain Injury Outcome
Targeting the Ubiquitin Proteasome System to Develop Treatment for Traumatic Brain Injuries
To further explores the effect TBI has on proteasome composition and activity in the brain
To assess the effect of inhibiting immunoproteasome activity
The Alternate Renin Angiotensin System as a Therapeutic Target for Traumatic Brain Injury
Evaluate if administration of Ang (1-7) at different time points after injury enhances recovery
Determine whether MasR signaling is beneficial to injury recovery
The Ferret as a Gyrencephalic Model for Traumatic Brain Injury
Determine the optimum timing and number of blast injuries needed to produce the pathological changes indicative of blast injury. These results will be compared to human data.
Evaluate the behavioral changes in ferrets exposed to these blast models
The Neural Basis for Post-traumatic Headache and its Link to Anxiety and Depression
Principal Investigator: Alexander Chesler, Ph.D.
Aim: To functionally dissect the classes of sensory neurons targeting the meninges to better understand the changes they undergo post-injury. It will also determine how these changes affect the neural circuits in the brain and determine the effect these neurons have on headache, anxiety, and depression.
Keywords: headache; migraine; meningeal nociceptors; neural circuits; TBI; depression; anxiety