Preclinical Publications


2021 Preclinical Publications

Bradshaw, D. V., Jr, Knutsen, A. K., Korotcov, A., Sullivan, G. M., Radomski, K. L., Dardzinski, B. J., Zi, X., McDaniel, D. P., & Armstrong, R. C. (2021). Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measuresActa neuropathologica communications9(1), 89.

Attilio, P. J., Snapper, D. M., Rusnak, M., Isaac, A., Soltis, A. R., Wilkerson, M. D., Dalgard, C. L., & Symes, A. J. (2021). Transcriptomic Analysis of Mouse Brain After Traumatic Brain Injury Reveals That the Angiotensin Receptor Blocker Candesartan Acts Through Novel PathwaysFrontiers in neuroscience15, 636259.

Chen, H., Kevala, K., Aflaki, E., Marugan, J., & Kim, H. Y. (2021). GPR110 ligands reduce chronic optic tract gliosis and visual deficit following repetitive mild traumatic brain injury in miceJournal of neuroinflammation18(1), 157.

Desai, A., Chen, H., Kevala, K., & Kim, H. Y. (2021). Higher n-3 Polyunsaturated Fatty Acid Diet Improves Long-Term Neuropathological and Functional Outcome after Repeated Mild Traumatic Brain InjuryJournal of neurotrauma, 10.1089/neu.2021.0096. Advance online publication.

Kim, J. H., Dodd, S., Ye, F. Q., Knutsen, A. K., Nguyen, D., Wu, H., Su, S., Mastrogiacomo, S., Esparza, T. J., Swenson, R. E., & Brody, D. L. (2021). Sensitive detection of extremely small iron oxide nanoparticles in living mice using MP2RAGE with advanced image co-registrationScientific reports11(1), 106. Link:

Nonaka, M., Taylor, W. W., Bukalo, O., Tucker, L. B., Fu, A. H., Kim, Y., McCabe, J. T., & Holmes, A. (2021). Behavioral and Myelin-Related Abnormalities after Blast-Induced Mild Traumatic Brain Injury in Mice. Journal of neurotrauma, 10.1089/neu.2020.7254. Advance online publication.

Russell, A. L., Miller, L., Yi, H., Keil, R., Handa, R. J., & Wu, T. J. (2021). Knockout of the circadian gene, Per2, disrupts corticosterone secretion and results in depressive-like behaviors and deficits in startle responses. BMC neuroscience, 22(1), 5. Link:

Schwerin, S. C., Chatterjee, M., Hutchinson, E. B., Djankpa, F. T., Armstrong, R. C., McCabe, J. T., Perl, D. P., & Juliano, S. L. (2021). Expression of GFAP and Tau Following Blast Exposure in the Cerebral Cortex of Ferrets. Journal of neuropathology and experimental neurology, 80(2), 112–128. Link:

Su, S., Esparza, T. J., Nguyen, D., Mastrogiacomo, S., Kim, J. H., & Brody, D. L. (2021). Pharmacokinetics of Single Domain Antibodies and Conjugated Nanoparticles Using a Hybrid near Infrared MethodInternational journal of molecular sciences22(16), 8695.

Tucker, L. B., Fu, A. H., & McCabe, J. T. (2021). Hippocampal-Dependent Cognitive Dysfunction following Repeated Diffuse Rotational Brain Injury in Male and Female Mice. Journal of neurotrauma, 10.1089/neu.2021.0025. Advance online publication.

2020 Preclinical Publications 

Asamoah., Bosomtwi, A., Dardzinski, B. J., Bernstock, J. D., Rizzi, S., Edenhofer, F., Pluchino, S., & Armstrong, R. C. (2020). Transplantation of induced neural stem cells (iNSCs) into chronically demyelinated corpus callosum ameliorates motor deficitsActa neuropathologica communications8(1), 84.

Desai, A., Chen, H., & Kim, H.-Y. (2020). Multiple Mild Traumatic Brain Injuries Lead to Visual Dysfunction in a Mouse Model. Journal of Neurotrauma, 37(2), 286–294. doi: 10.1089/neu.2019.6602

McCabe, J. T., & Tucker, L. B. (2020). Sex as a Biological Variable in Preclinical Modeling of Blast-Related Traumatic Brain InjuryFrontiers in Neurology, 11, 541050.

McNamara, E. H., Grillakis, A. A., Tucker, L. B., & McCabe, J. T. (2020). The closed-head impact model of engineered rotational acceleration (CHIMERA) as an application for traumatic brain injury pre-clinical research: A status report. Experimental Neurology333, 113409.

Nieves, M. D., Furmanski, O., & Doughty, M. L. (2020). Host sex and transplanted human induced pluripotent stem cell phenotype interact to influence sensorimotor recovery in a mouse model of cortical contusion injuryBrain research1748, 147120.

Nieves, M. D., Furmanski, O., & Doughty, M. L. (2020). Sensorimotor dysfunction in a mild mouse model of cortical contusion injury without significant neuronal loss is associated with increases in inflammatory proteins with innate but not adaptive immune functionsJournal of neuroscience research, 10.1002/jnr.24766. Advance online publication.

Reyes, L. D., Haight, T., Desai, A., Chen, H., Bosomtwi, A., Korotcov, A., Dardzinski, B., Kim, H. Y., & Pierpaoli, C. (2020). Investigation of the effect of dietary intake of omega-3 polyunsaturated fatty acids on trauma-induced white matter injury with quantitative diffusion MRI in miceJournal of Neuroscience Research

Vu, P. A., McNamara, E. H., Liu, J., Tucker, L. B., Fu, A. H., & McCabe, J. T. (2020). Behavioral responses following repeated bilateral frontal region closed head impacts and fear conditioning in male and female miceBrain Research1750, 147147. Advance online publication.


2018 Preclinical Study Publications

Bergstrom, H. C., Lipkin, A. M., Lieberman, A. G., Pinard, C. R., Gunduz-Cinar, O., Brockway, E. T., … Holmes, A. (2018). Dorsolateral Striatum Engagement Interferes with Early Discrimination Learning. Cell Reports, 23 (8), 2264–2272. doi:10.1016/j.celrep.2018.04.081

Hutchinson, E. B., Schwerin, S. C., Avram, A. V., Juliano, S. L., & Pierpaoli, C. (2018). Diffusion MRI and the Detection of Alterations Following Traumatic Brain Injury. Journal of Neuroscience Research, 96 (4), 612-625. doi:10.1002/jnr.24065

Kim, Y., Fu, A. H., Tucker, L. B., Liu, J., & McCabe, J. T. (2018). Characterization of Controlled Cortical Impact Devices by High-Speed Image Analysis. Journal of Neuroscience Research, 96 (4), 501-511. doi:10.1002/jnr.24099

Komlosh, M. E., Benjamini, D., Hutchinson, E. B., King, S., Haber, M., Avram, A. V., . . . Basser, P. J. (2018). Using Double Pulsed-field Gradient MRI to Study Tissue Microstructure in Traumatic Brain Injury (TBI). Microporous and Mesoporous Materials, 269, 156-159. doi:10.1016/j.micromeso.2017.05.030

Kovacs, Z. I., Tu, T., Sundby, M., Qureshi, F., Lewis, B. K., Jikaria, N., . . . Frank, J. A. (2018). MRI and Histological Evaluation of Pulsed Focused Ultrasound and Microbubbles Treatment Effects in the Brain. Theranostics, 8 (17), 4837-4855. doi:10.7150/thno.24512

Lischka, F. W., Efthymiou, A., Zhou, Q., Nieves, M. D., Mccormack, N. M., Wilkerson, M. D., . . . Doughty, M. L. (2018). Neonatal Mouse Cortical but not Isogenic Human Astrocyte Feeder Layers Enhance the Functional Maturation of Induced Pluripotent Stem Cell-derived Neurons in Culture. Glia, 66 (4), 725-748. doi:10.1002/glia.23278

Marion, C. M., Radomski, K. L., Cramer, N. P., Galdzicki, Z., & Armstrong, R. C. (2018). Experimental Traumatic Brain Injury Identifies Distinct Early and Late Phase Axonal Conduction Deficits of White Matter Pathophysiology, and Reveals Intervening Recovery. The Journal of Neuroscience, 38 (41), 8723-8736. doi:10.1523/jneurosci.0819-18.2018

Russell, A. L., Handa, R. J., & Wu, T. J. (2018). Sex-Dependent Effects of Mild Blast-induced Traumatic Brain Injury on Corticotropin-releasing Factor Receptor Gene Expression: Potential Link to Anxiety-like Behaviors. Neuroscience, 392, 1-12. doi:10.1016/j.neuroscience.2018.09.014

Russell, A. L., Richardson, M. R., Bauman, B. M., Hernandez, I. M., Saperstein, S., Handa, R. J., & Wu, T. J. (2018). Differential Responses of the HPA Axis to Mild Blast Traumatic Brain Injury in Male and Female Mice. Endocrinology, 159 (6), 2363-2375. doi:10.1210/en.2018-00203

Russell, A. L., Tasker, J. G., Lucion, A. B., Fiedler, J., Munhoz, C. D., Wu, T. J., & Deak, T. (2018). Factors Promoting Vulnerability to Dysregulated Stress Reactivity and Stress-related Disease. Journal of Neuroendocrinology, 30 (10). doi:10.1111/jne.12641

Sanchez, M. A., Armstrong, R. C. (2018). Postnatal Sonic Hedgehog (Shh) Responsive Cells Give Rise to Oligodendrocyte Lineage Cells During Myelination and in Adulthood Contribute to Remyelination. Experimental Neurology, 299, 122-136. doi:10.1016/j.expneurol.2017.10.010

Sanchez, M. A., Sullivan, G. M., & Armstrong, R. C. (2018). Genetic Detection of Sonic hedgehog (Shh) Expression and Cellular Response in the Progression of Acute Through Chronic Demyelination and Remyelination. Neurobiology of Disease, 115, 145-156. doi:10.1016/j.nbd.2018.04.003

Tu, T., Ibrahim, W. G., Jikaria, N., Munasinghe, J. P., Witko, J. A., Hammoud, D. A., & Frank, J. A. (2018). On the Detection of Cerebral Metabolic Depression in Experimental Traumatic Brain Injury Using Chemical Exchange Saturation Transfer (CEST)-weighted MRI. Scientific Reports, 8 (1). doi:10.1038/s41598-017-19094-z

Tucker, L. B., Velosky, A. G., & McCabe, J. T. (2018). Applications of the Morris Water Maze in Translational Traumatic Brain Injury Research. Neuroscience & Biobehavioral Reviews, 88, 187-200. doi:10.1016/j.neubiorev.2018.03.010

Vu, P. A., Tucker, L. B., Liu, J., Mcnamara, E. H., Tran, T., Fu, A. H., . . . McCabe, J. T. (2018). Transient Disruption of Mouse Home Cage Activities and Assessment of Orexin Immunoreactivity Following Concussive-or Blast-induced Brain Injury. Brain Research, 1700, 138-151. doi:10.1016/j.brainres.2018.08.034